Top 10 Randomized Clinical Trial Abstracts

See Dr. Machtay’s selections for ASTRO 2008 sessions highlighting the latest advances in prostate, head and neck, breast, and GI cancers. Dr. Machtay has ranked these randomized clinical trial abstracts in the order of importance. Dr. Machtay is Walter J. Curran Professor and Vice Chair, Department of Radiation Oncology, Jefferson Medical College, Philadelphia.

TOP 10 RANDOMIZED CLINICAL TRIALS

1. Abstract 66: GP Swanson
   Update of SWOG 8794: adjuvant radiotherapy for pT3 prostate cancer improves metastasis free survival.
2. Abstract 67: J Bourhis
   Accelerated versus conventional radiotherapy with concomitant chemotherapy in locally advanced head and neck carcinomas: results of a phase III randomized trial.
3. Abstract 60: TJ Whelan
   Long-term results of a randomized trial of accelerated hypofractionated whole breast irradiation following breast conserving surgery in women with node-negative breast cancer.
4. Abstract 218: D Kwong
   A randomized trial comparing intensity modulated radiotherapy versus 2-dimensional radiotherapy for nasopharyngeal carcinoma.
5. Abstract 65: M Bolla
   Ten year results of long term adjuvant androgen deprivation with goserelin in patients with locally advanced prostate cancer treated with radiotherapy: a phase III EORTC study.
6. Abstract 69: Q Le
   Palifermin reduces severe oral mucositis in subjects with locally advanced head and neck cancer undergoing chemoradiotherapy.
7. Abstract 165: JM Crook
   Final report of a Canadian phase III trial of 3 vs 8 months neoadjuvant androgen deprivation prior to 66 gray external beam radiotherapy for clinically localized prostate cancer.
8. Abstract 214: V Beckendorf
   70 Gy versus (vs) 80 Gy dose escalation Getug 06 French trial for localized prostate cancer: mature results.
9. Abstract 61: D Sebag-Montefiore
   The impact of short course pre-operative radiotherapy on patients’ quality of life: data from the MRC CR07/NCIC C016 randomised clinical trial in patients with rectal cancer.
10. Abstract 215: KA Skladowski
    Weekend breaks have no impact on the outcome of head and neck cancer when definitive radiotherapy is accelerated–results of phase III clinical trial (CAIR-2).

From: OncologySTAT.